Manuel J.T. Carrondo

Research interests

Publications

• Current challenges in biotherapeutic particles manufacturing

  Expert Opinion on Biological Therapy · 2019 · 10.1080/14712598.2020.1693541

• Improved virus purification processes for vaccines and gene therapy

  Biotechnology and Bioengineering · 2015 · 10.1002/bit.25545

• Metabolic responses of CHO cells to limitation of key amino acids

  Biotechnology and Bioengineering · 2014 · 10.1002/bit.25266

• Metabolic signatures of GS‐CHO cell clones associated with butyrate treatment and culture phase transition

  Biotechnology and Bioengineering · 2013 · 10.1002/bit.24983

• Insect cells as a production platform of complex virus-like particles

  Expert Review of Vaccines · 2013 · 10.1586/erv.12.153

• Microencapsulation Technology: A Powerful Tool for Integrating Expansion and Cryopreservation of Human Embryonic Stem Cells

  PLoS ONE · 2011 · 10.1371/journal.pone.0023212

• Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

  Hepatology · 2011 · 10.1002/hep.24760

• Large-scale production and purification of VLP-based vaccines

  Journal of Invertebrate Pathology · 2011 · 10.1016/j.jip.2011.05.004

• Virus-like particles in vaccine development

  Expert Review of Vaccines · 2010 · https://doi.org/10.1586/erv.10.115

• Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control

  Journal of Biotechnology · 2010 · 10.1016/j.jbiotec.2010.06.015

• Extending Hepatocyte Functionality for Drug-Testing Applications Using High-Viscosity Alginate–Encapsulated Three-Dimensional Cultures in Bioreactors

  Tissue Engineering Part C Methods · 2010 · 10.1089/ten.tec.2009.0784

• Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative

  Biotechnology Advances · 2009 · 10.1016/j.biotechadv.2009.05.003

• Cell density effect in the baculovirus‐insect cells system: A quantitative analysis of energetic metabolism

  Biotechnology and Bioengineering · 2009 · 10.1002/bit.22364

• Hybrid elementary flux analysis/nonparametric modeling: application for bioprocess control

  BMC Bioinformatics · 2007 · 10.1186/1471-2105-8-30

• Anion-exchange membrane chromatography for purification of rotavirus-like particles

  Journal of Membrane Science · 2007 · 10.1016/j.memsci.2007.12.021

• Purification of retroviral vectors for clinical application: Biological implications and technological challenges

  Journal of Biotechnology · 2006 · 10.1016/j.jbiotec.2006.07.028

• Downstream processing of triple layered rotavirus like particles

  Journal of Biotechnology · 2006 · 10.1016/j.jbiotec.2006.08.002

• Triple layered rotavirus VLP production: Kinetics of vector replication, mRNA stability and recombinant protein production

  Journal of Biotechnology · 2005 · 10.1016/j.jbiotec.2005.03.026

• A Procedure for High-Yield Spore Production by Bacillus s ubtilis

  Biotechnology Progress · 2005 · 10.1021/bp050062z

• Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells

  Enzyme and Microbial Technology · 2000 · 10.1016/s0141-0229(00)00151-4

• Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells

  Biotechnology and Bioengineering · 1999 · 10.1002/(sici)1097-0290(1999)66:2<104::aid-bit3>3.0.co;2-#

• Model for carbon metabolism in biological phosphorus removal processes based on in vivo13C-NMR labelling experiments

  Water Research · 1996 · 10.1016/0043-1354(96)00035-8

• Competition between nitrate and nitrite reduction in denitrification by Pseudomonas fluorescens

  Biotechnology and Bioengineering · 1995 · 10.1002/bit.260460512

• Nitrite inhibition of denitrification by Pseudomonas fluorescens

  Biotechnology and Bioengineering · 1995 · 10.1002/bit.260460303

• Effect of hydrogen sulfide on growth of sulfate reducing bacteria

  Biotechnology and Bioengineering · 1992 · 10.1002/bit.260400506

Current projects

No projects listed.