Ulrike Holzgrabe

Research interests

Publications

• Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor

  Journal of Biological Chemistry · 2016 · https://doi.org/10.1074/jbc.m116.735431

• ‘Pro et contra’ ionic liquid drugs – Challenges and opportunities for pharmaceutical translation

  European Journal of Pharmaceutics and Biopharmaceutics · 2015 · https://doi.org/10.1016/j.ejpb.2015.05.027

• Routine quality control of medicines in developing countries: Analytical challenges, regulatory infrastructures and the prevalence of counterfeit medicines in Tanzania

  TrAC Trends in Analytical Chemistry · 2015 · https://doi.org/10.1016/j.trac.2015.11.009

• Acetylcholinesterase Inhibitors with Photoswitchable Inhibition of β-Amyloid Aggregation

  ACS Chemical Neuroscience · 2014 · https://doi.org/10.1021/cn500016p

• The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

  Nature Communications · 2012 · https://doi.org/10.1038/ncomms2028

• Charged aerosol detection in pharmaceutical analysis

  Journal of Pharmaceutical and Biomedical Analysis · 2012 · https://doi.org/10.1016/j.jpba.2012.03.019

• Quaternary Ammonium Salts and Their Antimicrobial Potential: Targets or Nonspecific Interactions?

  ChemMedChem · 2011 · https://doi.org/10.1002/cmdc.201100404

• Quantitative NMR spectroscopy in pharmaceutical applications

  Progress in Nuclear Magnetic Resonance Spectroscopy · 2010 · https://doi.org/10.1016/j.pnmrs.2010.05.001

• Analytical challenges in drug counterfeiting and falsification—The NMR approach

  Journal of Pharmaceutical and Biomedical Analysis · 2010 · https://doi.org/10.1016/j.jpba.2010.12.017

• Rational design of dualsteric GPCR ligands: quests and promise

  British Journal of Pharmacology · 2010 · https://doi.org/10.1111/j.1476-5381.2009.00601.x

• NMR techniques in biomedical and pharmaceutical analysis

  Journal of Pharmaceutical and Biomedical Analysis · 2010 · https://doi.org/10.1016/j.jpba.2010.12.023

• Allosteric ligands for G protein-coupled receptors: A novel strategy with attractive therapeutic opportunities

  Medicinal Research Reviews · 2009 · https://doi.org/10.1002/med.20166

• Penetration of Antibacterials into Bone

  Clinical Pharmacokinetics · 2009 · https://doi.org/10.2165/00003088-200948020-00002

• Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

  The FASEB Journal · 2008 · https://doi.org/10.1096/fj.08-114751

• Systematic Comparison of the Population Pharmacokinetics and Pharmacodynamics of Piperacillin in Cystic Fibrosis Patients and Healthy Volunteers

  Antimicrobial Agents and Chemotherapy · 2007 · https://doi.org/10.1128/aac.01477-06

• Targeting acetylcholinesterase to treat neurodegeneration

  Expert Opinion on Therapeutic Targets · 2007 · https://doi.org/10.1517/14728222.11.2.161

• Quantitative NMR spectroscopy—Applications in drug analysis

  Journal of Pharmaceutical and Biomedical Analysis · 2005 · https://doi.org/10.1016/j.jpba.2005.01.050

• Evaluation by Monte Carlo Simulation of the Pharmacokinetics of Two Doses of Meropenem Administered Intermittently or as a Continuous Infusion in Healthy Volunteers

  Antimicrobial Agents and Chemotherapy · 2005 · https://doi.org/10.1128/aac.49.5.1881-1889.2005

• Comparison of Pharmacological Activities of Three Distinct κ Ligands (Salvinorin A, TRK-820 and 3FLB) on κ Opioid Receptors in Vitro and Their Antipruritic and Antinociceptive Activities in Vivo

  Journal of Pharmacology and Experimental Therapeutics · 2004 · https://doi.org/10.1124/jpet.104.073668

• Vibrational spectroscopic characterization of fluoroquinolones

  Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · 2004 · https://doi.org/10.1016/j.saa.2004.11.014

• Photocatalyzed [2 + 2 + 2]-Cycloaddition of Nitriles with Acetylene: An Effective Method for the Synthesis of 2-Pyridines under Mild Conditions

  The Journal of Organic Chemistry · 2002 · https://doi.org/10.1021/jo011032n

• NMR spectroscopy in pharmacy

  Journal of Pharmaceutical and Biomedical Analysis · 1998 · https://doi.org/10.1016/s0731-7085(97)00276-8

Current projects

No projects listed.