Michal Hocek

Research interests

Publications

• Enzymatic Synthesis of Base-Functionalized Nucleic Acids for Sensing, Cross-linking, and Modulation of Protein–DNA Binding and Transcription

  Accounts of Chemical Research · 2019 · 10.1021/acs.accounts.9b00195

• Pyrrolo[2,3‐ d ]pyrimidine (7‐deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

  Medicinal Research Reviews · 2017 · 10.1002/med.21465

• Pyrrolo[2,3‐ d ]pyrimidine (7‐deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

  Medicinal Research Reviews · 2017 · 10.1002/med.21465

• A Rotational BODIPY Nucleotide: An Environment‐Sensitive Fluorescence‐Lifetime Probe for DNA Interactions and Applications in Live‐Cell Microscopy

  Angewandte Chemie International Edition · 2015 · 10.1002/anie.201507922

• A Rotational BODIPY Nucleotide: An Environment‐Sensitive Fluorescence‐Lifetime Probe for DNA Interactions and Applications in Live‐Cell Microscopy

  Angewandte Chemie International Edition · 2015 · 10.1002/anie.201507922

• Inside Cover: A Rotational BODIPY Nucleotide: An Environment‐Sensitive Fluorescence‐Lifetime Probe for DNA Interactions and Applications in Live‐Cell Microscopy (Angew. Chem. Int. Ed. 1/2016)

  Angewandte Chemie International Edition · 2015 · 10.1002/anie.201510985

• Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

  The Journal of Organic Chemistry · 2014 · 10.1021/jo5020799

• Systematic exploration of a class of hydrophobic unnatural base pairs yields multiple new candidates for the expansion of the genetic alphabet

  Nucleic Acids Research · 2014 · 10.1093/nar/gku715

• Synthesis of Base-Modified 2′-Deoxyribonucleoside Triphosphates and Their Use in Enzymatic Synthesis of Modified DNA for Applications in Bioanalysis and Chemical Biology

  The Journal of Organic Chemistry · 2014 · 10.1021/jo5020799

• Vinylsulfonamide and Acrylamide Modification of DNA for Cross‐linking with Proteins

  Angewandte Chemie International Edition · 2013 · 10.1002/anie.201303577

• Nucleobase modification as redox DNA labelling for electrochemical detection

  Chemical Society Reviews · 2011 · 10.1039/c1cs15049a

• Nucleobase modification as redox DNA labelling for electrochemical detection

  Chemical Society Reviews · 2011 · 10.1039/c1cs15049a

• Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines

  Journal of Medicinal Chemistry · 2011 · 10.1021/jm2005173

• Synthesis and Photophysical Properties of Biaryl-Substituted Nucleos(t)ides. Polymerase Synthesis of DNA Probes Bearing Solvatochromic and pH-Sensitive Dual Fluorescent and 19 F NMR Labels

  The Journal of Organic Chemistry · 2011 · 10.1021/jo202321g

• Direct Polymerase Synthesis of Reactive Aldehyde‐Functionalized DNA and Its Conjugation and Staining with Hydrazines

  Angewandte Chemie International Edition · 2009 · 10.1002/anie.200905556

• C -Nucleosides: Synthetic Strategies and Biological Applications

  Chemical Reviews · 2009 · https://doi.org/10.1021/cr9002165

• Aminophenyl‐ and Nitrophenyl‐Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection

  Angewandte Chemie International Edition · 2008 · 10.1002/anie.200705088

• Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids

  Organic & Biomolecular Chemistry · 2008 · 10.1039/b803664k

• Aminophenyl‐ and Nitrophenyl‐Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection

  Angewandte Chemie International Edition · 2008 · 10.1002/anie.200705088

• Cross-coupling reactions of nucleoside triphosphates followed by polymerase incorporation. Construction and applications of base-functionalized nucleic acids

  Organic & Biomolecular Chemistry · 2008 · 10.1039/b803664k

• Base‐Modified DNA Labeled by [Ru(bpy)3]2+ and [Os(bpy)3]2+ Complexes: Construction by Polymerase Incorporation of Modified Nucleoside Triphosphates, Electrochemical and Luminescent Properties, and Applications

  Chemistry - A European Journal · 2008 · 10.1002/chem.200801538

• An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross‐Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR

  Chemistry - A European Journal · 2007 · 10.1002/chem.200700220

• Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry, and Bioanalytical Applications

  Chemistry - A European Journal · 2007 · 10.1002/chem.200701249

• An Efficient Method for the Construction of Functionalized DNA Bearing Amino Acid Groups through Cross‐Coupling Reactions of Nucleoside Triphosphates Followed by Primer Extension or PCR

  Chemistry - A European Journal · 2007 · 10.1002/chem.200700220

• Ferrocenylethynyl Derivatives of Nucleoside Triphosphates: Synthesis, Incorporation, Electrochemistry, and Bioanalytical Applications

  Chemistry - A European Journal · 2007 · 10.1002/chem.200701249

• Direct C−H Arylation of Purines: Development of Methodology and Its Use in Regioselective Synthesis of 2,6,8-Trisubstituted Purines

  Organic Letters · 2006 · 10.1021/ol062324j

• Direct C−H Arylation of Purines: Development of Methodology and Its Use in Regioselective Synthesis of 2,6,8-Trisubstituted Purines

  Organic Letters · 2006 · 10.1021/ol062324j

• Cross-coupling reactions of unprotected halopurine bases, nucleosides, nucleotides and nucleoside triphosphates with 4-boronophenylalanine in water. Synthesis of (purin-8-yl)- and (purin-6-yl)phenylalanines

  Organic & Biomolecular Chemistry · 2006 · 10.1039/b604010a

• Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides

  Journal of Medicinal Chemistry · 2005 · 10.1021/jm050335x

• Cytostatic 6-Arylpurine Nucleosides. 6. SAR in Anti-HCV and Cytostatic Activity of Extended Series of 6-Hetarylpurine Ribonucleosides

  Journal of Medicinal Chemistry · 2005 · 10.1021/jm050335x

• An Efficient Synthesis of 2-Substituted 6-Methylpurine Bases and Nucleosides by Fe- or Pd-Catalyzed Cross-Coupling Reactions of 2,6-Dichloropurines

  The Journal of Organic Chemistry · 2003 · 10.1021/jo034351i

• Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal‐ or Organometal‐Mediated C−C Bond‐Forming Reactions

  European Journal of Organic Chemistry · 2002 · 10.1002/ejoc.200390025

• Syntheses of Purines Bearing Carbon Substituents in Positions 2, 6 or 8 by Metal‐ or Organometal‐Mediated C−C Bond‐Forming Reactions

  European Journal of Organic Chemistry · 2002 · 10.1002/ejoc.200390025

• Cytostatic 6-Arylpurine Nucleosides III. Synthesis and Structure-Activity Relationship Study in Cytostatic Activity of 6-Aryl-, 6-Hetaryl- and 6-Benzylpurine Ribonucleosides

  Collection of Czechoslovak Chemical Communications · 2001 · 10.1135/cccc20010483

• Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides: Application of the Suzuki−Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids

  Journal of Medicinal Chemistry · 2000 · https://doi.org/10.1021/jm991167+

Current projects

No projects listed.