Qidong You

Research interests

Publications

• Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

  Free Radical Biology and Medicine · 2021 · 10.1016/j.freeradbiomed.2021.03.034

• Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

  Journal of Medicinal Chemistry · 2020 · 10.1021/acs.jmedchem.9b02058

• Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

  Science Advances · 2019 · 10.1126/sciadv.aax2277

• Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

  Journal of Medicinal Chemistry · 2019 · https://doi.org/10.1021/acs.jmedchem.9b00940

• CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

  Redox Biology · 2019 · https://doi.org/10.1016/j.redox.2019.101266

• Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

  Journal of Medicinal Chemistry · 2019 · https://doi.org/10.1021/acs.jmedchem.9b01039

• Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

  European Journal of Medicinal Chemistry · 2018 · https://doi.org/10.1016/j.ejmech.2018.01.063

• Prodrug strategy for cancer cell-specific targeting: A recent overview

  European Journal of Medicinal Chemistry · 2017 · 10.1016/j.ejmech.2017.08.010

• NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

  Oncotarget · 2016 · 10.18632/oncotarget.12435

• The Keap1–Nrf2–ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

  Medicinal Research Reviews · 2016 · https://doi.org/10.1002/med.21396

• Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

  Journal of Medicinal Chemistry · 2016 · 10.1021/acs.jmedchem.6b00586

• An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

  Scientific Reports · 2016 · 10.1038/srep26585

• Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

  Journal of Medicinal Chemistry · 2014 · https://doi.org/10.1021/jm5000529

• Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF‐1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

  Molecular Carcinogenesis · 2013 · 10.1002/mc.22052

• Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells

  Toxicology · 2013 · 10.1016/j.tox.2013.07.013

• Drug resistance associates with activation of Nrf2 in MCF ‐7/ DOX cells, and wogonin reverses it by down‐regulating Nrf2‐mediated cellular defense response

  Molecular Carcinogenesis · 2012 · 10.1002/mc.21921

• Synthesis and evaluation of anti-tubercular and antibacterial activities of new 4-(2,6-dichlorobenzyloxy)phenyl thiazole, oxazole and imidazole derivatives. Part 2

  European Journal of Medicinal Chemistry · 2012 · 10.1016/j.ejmech.2012.01.007

• Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells

  Cancer Letters · 2010 · 10.1016/j.canlet.2010.04.022

• Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

  Cancer Letters · 2009 · 10.1016/j.canlet.2009.01.016

• Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

  Cancer Letters · 2007 · https://doi.org/10.1016/j.canlet.2007.06.014

• Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells

  Biochemical and Biophysical Research Communications · 2007 · https://doi.org/10.1016/j.bbrc.2007.06.155

• Anti-hepatitis B virus activity of wogonin in vitro and in vivo

  Antiviral Research · 2007 · 10.1016/j.antiviral.2007.01.002

• Gambogic Acid Inhibits Proliferation of Human Lung Carcinoma SPC-A1 Cells in Vivo and in Vitro and Represses Telomerase Activity and Telomerase Reverse Transcriptase mRNA Expression in the Cells

  Biological and Pharmaceutical Bulletin · 2004 · 10.1248/bpb.27.1769

Current projects

No projects listed.