David H. Sherman

Research interests

Publications

• Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria

  Journal of Natural Products · 2015 · 10.1021/acs.jnatprod.5b00301

• Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

  Nature Chemistry · 2015 · 10.1038/nchem.2285

• Characterization of Cyanobacterial Hydrocarbon Composition and Distribution of Biosynthetic Pathways

  PLoS ONE · 2014 · 10.1371/journal.pone.0085140

• Structure of a modular polyketide synthase

  Nature · 2014 · https://doi.org/10.1038/nature13423

• Structural rearrangements of a polyketide synthase module during its catalytic cycle

  Nature · 2014 · 10.1038/nature13409

• Fungal Origins of the Bicyclo[2.2.2]diazaoctane Ring System of Prenylated Indole Alkaloids

  Journal of Natural Products · 2012 · 10.1021/np200954v

• Diversity of P450 enzymes in the biosynthesis of natural products

  Natural Product Reports · 2012 · https://doi.org/10.1039/c2np20020a

• Enantiomeric Natural Products: Occurrence and Biogenesis

  Angewandte Chemie International Edition · 2012 · 10.1002/anie.201107204

• Meta-omic Characterization of the Marine Invertebrate Microbial Consortium That Produces the Chemotherapeutic Natural Product ET-743

  ACS Chemical Biology · 2011 · 10.1021/cb200244t

• Automated genome mining for natural products

  BMC Bioinformatics · 2009 · 10.1186/1471-2105-10-185

• Metamorphic enzyme assembly in polyketide diversification

  Nature · 2009 · 10.1038/nature07870

• The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 PikC from Streptomyces venezuelae

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.m605478200

• Biosynthetic Characterization and Chemoenzymatic Assembly of the Cryptophycins. Potent Anticancer Agents from Nostoc Cyanobionts

  ACS Chemical Biology · 2006 · 10.1021/cb6004307

• Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from “Candidatus Endobugula sertula”, the Uncultivated Microbial Symbiont of the Marine Bryozoan Bugula neritina

  Journal of Natural Products · 2006 · https://doi.org/10.1021/np060361d

• bryA

  Chemistry & Biology · 2004 · 10.1016/j.chembiol.2004.08.018

• Isolation and Characterization of Novel Marine-Derived Actinomycete Taxa Rich in Bioactive Metabolites

  Applied and Environmental Microbiology · 2004 · 10.1128/aem.70.12.7520-7529.2004

• Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery

  Natural Product Reports · 2004 · 10.1039/b301384g

• Biosynthetic Pathway and Gene Cluster Analysis of Curacin A, an Antitubulin Natural Product from the Tropical Marine Cyanobacterium Lyngbya majuscula

  Journal of Natural Products · 2004 · 10.1021/np0499261

• The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit

  Gene · 2002 · 10.1016/s0378-1119(02)00860-0

• Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

  Chemistry & Biology · 1999 · 10.1016/s1074-5521(99)80040-4

• A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae : Architecture of metabolic diversity

  Proceedings of the National Academy of Sciences · 1998 · https://doi.org/10.1073/pnas.95.21.12111

• MOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS

  Annual Review of Genetics · 1990 · https://doi.org/10.1146/annurev.ge.24.120190.000345

• Structure and deduced function of the granaticin‐producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

  The EMBO Journal · 1989 · 10.1002/j.1460-2075.1989.tb08413.x

• Molecular Biology of the H-2 Histocompatibility Complex

  Science · 1986 · 10.1126/science.3726537

• Immunoprecipitation of cell surface structures of cloned cytotoxic T lymphocytes by clone-specific antisera.

  Proceedings of the National Academy of Sciences · 1984 · 10.1073/pnas.81.2.573

Current projects

No projects listed.