Lei Zheng

Research interests

Publications

• Combination strategies to maximize the benefits of cancer immunotherapy

  Journal of Hematology & Oncology · 2021 · https://doi.org/10.1186/s13045-021-01164-5

• Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

  Journal of Clinical Oncology · 2020 · https://doi.org/10.1200/jco.20.00590

• The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

  Nature Reviews Clinical Oncology · 2020 · https://doi.org/10.1038/s41571-020-0363-5

• Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

  Journal of Hematology & Oncology · 2020 · https://doi.org/10.1186/s13045-020-00862-w

• Sonodynamic therapy-derived multimodal synergistic cancer therapy

  Cancer Letters · 2020 · https://doi.org/10.1016/j.canlet.2020.10.037

• Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.05.065

• Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape

  Journal for ImmunoTherapy of Cancer · 2019 · https://doi.org/10.1186/s40425-019-0667-0

• Survival in Locally Advanced Pancreatic Cancer After Neoadjuvant Therapy and Surgical Resection

  Annals of Surgery · 2018 · https://doi.org/10.1097/sla.0000000000002753

• HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma

  Journal of Clinical Oncology · 2017 · https://doi.org/10.1200/jco.2017.74.9564

• Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma

  Annals of Surgery · 2017 · https://doi.org/10.1097/sla.0000000000002234

• Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.03.037

• LncRNA‐PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis

  EMBO Reports · 2017 · https://doi.org/10.15252/embr.201744147

• STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

  Science Translational Medicine · 2015 · https://doi.org/10.1126/scitranslmed.aaa4306

• Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells

  OncoImmunology · 2015 · https://doi.org/10.1080/2162402x.2015.1016700

• Current progress in immunotherapy for pancreatic cancer

  Cancer Letters · 2015 · https://doi.org/10.1016/j.canlet.2015.12.020

• PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

  Journal of Immunotherapy · 2014 · https://doi.org/10.1097/cji.0000000000000062

• The Impact of Postoperative Complications on the Administration of Adjuvant Therapy Following Pancreaticoduodenectomy for Adenocarcinoma

  Annals of Surgical Oncology · 2014 · https://doi.org/10.1245/s10434-014-3722-6

• Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

  Cancer Immunology Research · 2014 · https://doi.org/10.1158/2326-6066.cir-14-0027

• Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma

  Cancer · 2014 · https://doi.org/10.1002/cncr.29161

• The Association Between Chemoradiation-related Lymphopenia and Clinical Outcomes in Patients With Locally Advanced Pancreatic Adenocarcinoma

  American Journal of Clinical Oncology · 2013 · https://doi.org/10.1097/coc.0b013e3182940ff9

• Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma

  Gastroenterology · 2013 · https://doi.org/10.1053/j.gastro.2012.12.042

Current projects

No projects listed.