Viktor Brabec

Research interests

Publications

• Towards Novel Photodynamic Anticancer Agents Generating Superoxide Anion Radicals: A Cyclometalated Ir III Complex Conjugated to a Far‐Red Emitting Coumarin

  Angewandte Chemie International Edition · 2019 · https://doi.org/10.1002/anie.201901268

• Ruthenium coordination compounds of biological and biomedical significance. DNA binding agents

  Coordination Chemistry Reviews · 2018 · https://doi.org/10.1016/j.ccr.2018.07.012

• Cytotoxic platinum coordination compounds. DNA binding agents

  Coordination Chemistry Reviews · 2017 · https://doi.org/10.1016/j.ccr.2017.04.013

• Pt( iv ) derivatives of cisplatin and oxaliplatin with phenylbutyrate axial ligands are potent cytotoxic agents that act by several mechanisms of action

  Chemical Science · 2016 · https://doi.org/10.1039/c5sc04205d

• Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

  Nature Chemistry · 2011 · https://doi.org/10.1038/nchem.1206

• Organometallic Half-Sandwich Iridium Anticancer Complexes

  Journal of Medicinal Chemistry · 2011 · https://doi.org/10.1021/jm2000932

• A potent cytotoxic photoactivated platinum complex

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0707742105

• DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity

  Drug Resistance Updates · 2006 · https://doi.org/10.1016/j.drup.2006.05.002

• Modifications of DNA by platinum complexes

  Drug Resistance Updates · 2005 · https://doi.org/10.1016/j.drup.2005.04.006

• DNA Interactions of Monofunctional Organometallic Ruthenium(II) Antitumor Complexes in Cell-free Media

  Biochemistry · 2003 · https://doi.org/10.1021/bi034933u

• DNA Modifications by antitumor platinum and ruthenium compounds: Their recognition and repair

  Progress in nucleic acid research and molecular biology · 2002 · https://doi.org/10.1016/s0079-6603(02)71040-4

• DNA Modifications by a Novel Bifunctional Trinuclear Platinum Phase I Anticancer Agent

  Biochemistry · 1999 · https://doi.org/10.1021/bi990124s

• Correlation between Cytotoxicity and DNA Binding of Polypyridyl Ruthenium Complexes

  Biochemistry · 1995 · https://doi.org/10.1021/bi00038a034

• DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

  Proceedings of the National Academy of Sciences · 1993 · https://doi.org/10.1073/pnas.90.11.5345

Current projects

No projects listed.