Iris Dotan

Research interests

Publications

• Global evolution of inflammatory bowel disease across epidemiologic stages

  Nature · 2025 · https://doi.org/10.1038/s41586-025-08940-0

• Gut Microbiome Composition Is Associated With Future Onset of Crohn’s Disease in Healthy First-Degree Relatives

  Gastroenterology · 2023 · 10.1053/j.gastro.2023.05.032

• Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus

  ˜The œLancet. Gastroenterology & hepatology · 2022 · 10.1016/s2468-1253(22)00021-8

• The Crohn's disease exclusion diet for induction and maintenance of remission in adults with mild-to-moderate Crohn's disease (CDED-AD): an open-label, pilot, randomised trial

  ˜The œLancet. Gastroenterology & hepatology · 2021 · 10.1016/s2468-1253(21)00299-5

• Safety and efficacy of tofacitinib for treatment of ulcerative colitis: final analysis of OCTAVE Open, an open‐label, long‐term extension study with up to 7.0 years of treatment

  Alimentary Pharmacology & Therapeutics · 2021 · https://doi.org/10.1111/apt.16712

• Selecting End Points for Disease-Modification Trials in Inflammatory Bowel Disease: the SPIRIT Consensus From the IOIBD

  Gastroenterology · 2021 · 10.1053/j.gastro.2020.10.065

• STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD

  Gastroenterology · 2021 · https://doi.org/10.1053/j.gastro.2020.12.031

• Management of Patients With Crohn’s Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic: Results of an International Meeting

  Gastroenterology · 2020 · 10.1053/j.gastro.2020.04.002

• Gut microbiota density influences host physiology and is shaped by host and microbial factors

  eLife · 2019 · 10.7554/elife.40553

• Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD

  Gut · 2018 · 10.1136/gutjnl-2017-315494

• Infliximab-Related Infusion Reactions: Systematic Review

  Journal of Crohn s and Colitis · 2015 · 10.1093/ecco-jcc/jjv096

• Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis

  Gastroenterology · 2015 · https://doi.org/10.1053/j.gastro.2015.10.041

• Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target

  The American Journal of Gastroenterology · 2015 · https://doi.org/10.1038/ajg.2015.233

• Levels of Drug and Antidrug Antibodies Are Associated With Outcome of Interventions After Loss of Response to Infliximab or Adalimumab

  Clinical Gastroenterology and Hepatology · 2014 · https://doi.org/10.1016/j.cgh.2014.07.029

• Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial

  The Lancet · 2014 · https://doi.org/10.1016/s0140-6736(14)60661-9

• Patient Factors That Increase Infliximab Clearance and Shorten Half-life in Inflammatory Bowel Disease

  Inflammatory Bowel Diseases · 2014 · 10.1097/mib.0000000000000212

• Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study

  Clinical Gastroenterology and Hepatology · 2013 · 10.1016/j.cgh.2013.04.034

• Doubling the infliximab dose versus halving the infusion intervals in Crohnʼs disease patients with loss of response

  Inflammatory Bowel Diseases · 2012 · https://doi.org/10.1002/ibd.22902

• European evidenced-based consensus on reproduction in inflammatory bowel disease

  Journal of Crohn s and Colitis · 2010 · 10.1016/j.crohns.2010.07.004

• The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Special situations

  Journal of Crohn s and Colitis · 2009 · https://doi.org/10.1016/j.crohns.2009.09.009

• CXCL12 Is a constitutive and inflammatory chemokine in the intestinal immune system

  Inflammatory Bowel Diseases · 2009 · https://doi.org/10.1002/ibd.21106

• Gut, inflammation and osteoporosis: basic and clinical concepts

  Gut · 2008 · 10.1136/gut.2006.117382

• Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

  Nature Cell Biology · 2006 · https://doi.org/10.1038/ncb1426

• Antibodies Against Laminaribioside and Chitobioside Are Novel Serologic Markers in Crohn’s Disease

  Gastroenterology · 2006 · 10.1053/j.gastro.2006.04.030

• Defects in CD8+ Regulatory T Cells in the Lamina Propria of Patients with Inflammatory Bowel Disease

  The Journal of Immunology · 2005 · 10.4049/jimmunol.174.9.5814

• The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells

  Gastroenterology · 2004 · 10.1053/j.gastro.2004.02.004

• Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells

  Gastroenterology · 2002 · 10.1053/gast.2002.36588

Current projects

No projects listed.