Juan Miguel Mosquera

Research interests

Publications

• Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer

  Journal of Clinical Investigation · 2020 · https://doi.org/10.1172/jci131041

• Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer

  Science Translational Medicine · 2019 · https://doi.org/10.1126/scitranslmed.aav0891

• Genomic correlates of clinical outcome in advanced prostate cancer

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1902651116

• Clinical features of neuroendocrine prostate cancer

  European Journal of Cancer · 2019 · https://doi.org/10.1016/j.ejca.2019.08.011

• Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-019-10873-y

• A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-18-1912

• Patient derived organoids to model rare prostate cancer phenotypes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04495-z

• Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-16-1154

• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4045

• Clonal evolution of chemotherapy-resistant urothelial carcinoma

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3692

• Integrative Clinical Genomics of Advanced Prostate Cancer

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.05.001

• Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response

  JAMA Oncology · 2015 · https://doi.org/10.1001/jamaoncol.2015.1313

• The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

  Cell Reports · 2015 · https://doi.org/10.1016/j.celrep.2015.07.012

• The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms6383

• Concurrent AURKA and MYCN Gene Amplifications Are Harbingers of Lethal TreatmentRelated Neuroendocrine Prostate Cancer

  Neoplasia · 2013 · https://doi.org/10.1593/neo.121550

• Punctuated Evolution of Prostate Cancer Genomes

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.03.021

• Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

  Nature Biotechnology · 2013 · https://doi.org/10.1038/nbt.2696

• Challenges in Recognizing Treatment-Related Neuroendocrine Prostate Cancer

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.41.5166

• Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity

  European Urology · 2012 · https://doi.org/10.1016/j.eururo.2012.08.053

Current projects

No projects listed.