Judith E. Karp

Research interests

Publications

• Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy

  JCI Insight · 2018 · 10.1172/jci.insight.120974

• Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments

  Cancer Biomarkers · 2017 · 10.3233/cbm-160336

• Minimal residual disease in acute myeloid leukaemia

  Nature Reviews Clinical Oncology · 2013 · 10.1038/nrclinonc.2013.100

• Prevention and Treatment of Cancer-Related Infections

  Journal of the National Comprehensive Cancer Network · 2012 · 10.6004/jnccn.2012.0146

• A clinically relevant population of leukemic CD34+CD38− cells in acute myeloid leukemia

  Blood · 2012 · 10.1182/blood-2011-06-364182

• A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response

  Blood · 2008 · 10.1182/blood-2008-09-177030

• Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

  Nature · 2008 · https://doi.org/10.1038/nature06468

• Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias

  Blood · 2006 · https://doi.org/10.1182/blood-2006-05-021873

• Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors

  Blood · 2006 · https://doi.org/10.1182/blood-2006-04-015743

• Combined DNA Methyltransferase and Histone Deacetylase Inhibition in the Treatment of Myeloid Neoplasms

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-0080

• SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

  Blood · 2003 · 10.1182/blood-2002-10-3023

• Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

  Nature Genetics · 2002 · https://doi.org/10.1038/ng955

• Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

  Blood · 2001 · https://doi.org/10.1182/blood.v97.11.3361

• Expression of breast cancer resistance protein in blast cells from patients with acute leukemia

  Blood · 2000 · 10.1182/blood.v96.1.365

• Expression of breast cancer resistance protein in blast cells from patients with acute leukemia

  Blood · 2000 · 10.1182/blood.v96.1.365.013k46_365_368

• Elevated Expression of the Apoptotic Regulator Mcl-1 at the Time of Leukemic Relapse

  Blood · 1998 · 10.1182/blood.v91.3.991.991_991_1000

• Association of Torulopsis glabrata infections with fluconazole prophylaxis in neutropenic bone marrow transplant patients

  Antimicrobial Agents and Chemotherapy · 1993 · 10.1128/aac.37.9.1847

• Increase inCandida kruseiInfection among Patients with Bone Marrow Transplantation and Neutropenia Treated Prophylactically with Fluconazole

  New England Journal of Medicine · 1991 · https://doi.org/10.1056/nejm199110313251803

• Potential Role of Tamoxifen in Prevention of Breast Cancer

  JNCI Journal of the National Cancer Institute · 1991 · 10.1093/jnci/83.20.1450

• From the Immunocompromised Host Society: The Design, Analysis, and Reporting of Clinical Trials on the Empirical Antibiotic Management of the Neutropenic Patient: Report of a Consensus Panel

  The Journal of Infectious Diseases · 1990 · https://doi.org/10.1093/infdis/161.3.397

• Phase I and pharmacodynamic study of taxol in refractory acute leukemias.

  PubMed · 1989

• Favorable outcome of invasive aspergillosis in patients with acute leukemia.

  Journal of Clinical Oncology · 1987 · 10.1200/jco.1987.5.12.1985

• Oral Norfloxacin for Prevention of Gram-Negative Bacterial Infections in Patients with Acute Leukemia and Granulocytopenia

  Annals of Internal Medicine · 1987 · 10.7326/0003-4819-106-1-1

• Autologous Bone Marrow Transplantation in Patients with Acute Nonlymphocytic Leukemia, Using ex Vivo Marrow Treatment with 4-Hydroperoxycyclophosphamide

  New England Journal of Medicine · 1986 · 10.1056/nejm198607173150301

• Empiric use of vancomycin during prolonged treatment-induced granulocytopenia. Randomized, double-blind, placebo-controlled clinical trial in patients with acute leukemia

  The American Journal of Medicine · 1986 · 10.1016/0002-9343(86)90257-3

Current projects

No projects listed.