Doron Lipson

Research interests

Publications

• Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

  Cell · 2022 · 10.1016/j.cell.2022.05.013

• Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

  Nature Medicine · 2018 · 10.1038/s41591-018-0134-3

• Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA

  Journal of Molecular Diagnostics · 2018 · 10.1016/j.jmoldx.2018.05.004

• A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal

  PLoS Computational Biology · 2018 · 10.1371/journal.pcbi.1005965

• Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

  Blood · 2016 · 10.1182/blood-2015-08-664649

• Broad, Hybrid Capture–Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches

  Clinical Cancer Research · 2015 · 10.1158/1078-0432.ccr-14-2683

• Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site

  JAMA Oncology · 2015 · 10.1001/jamaoncol.2014.216

• Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors

  Cancer Discovery · 2015 · 10.1158/2159-8290.cd-15-0285

• The distribution of BRAF gene fusions in solid tumors and response to targeted therapy

  International Journal of Cancer · 2015 · 10.1002/ijc.29825

• Emergence of Constitutively Active Estrogen Receptor-α Mutations in Pretreated Advanced Estrogen Receptor–Positive Breast Cancer

  Clinical Cancer Research · 2014 · https://doi.org/10.1158/1078-0432.ccr-13-2332

• Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

  Nature Communications · 2014 · https://doi.org/10.1038/ncomms4116

• New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing

  The Oncologist · 2014 · 10.1634/theoncologist.2013-0352

• Inflammatory Myofibroblastic Tumors Harbor Multiple Potentially Actionable Kinase Fusions

  Cancer Discovery · 2014 · 10.1158/2159-8290.cd-14-0377

• Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1407792111

• Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

  Nature Biotechnology · 2013 · https://doi.org/10.1038/nbt.2696

• Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors

  Genome Medicine · 2013 · 10.1186/gm453

• Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer

  Nature Medicine · 2013 · 10.1038/nm.3352

• Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas

  Cancer Discovery · 2013 · 10.1158/2159-8290.cd-13-0035

• Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

  Nature Medicine · 2012 · https://doi.org/10.1038/nm.2673

• Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity

  European Urology · 2012 · https://doi.org/10.1016/j.eururo.2012.08.053

• Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

  Science · 2011 · 10.1126/science.1200801

• GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

  BMC Bioinformatics · 2009 · 10.1186/1471-2105-10-48

• Discovering Motifs in Ranked Lists of DNA Sequences

  PLoS Computational Biology · 2007 · 10.1371/journal.pcbi.0030039

• Comparative genomic hybridization using oligonucleotide microarrays and total genomic DNA

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0407979101

• Two-State Allosteric Behavior in a Single-Domain Signaling Protein

  Science · 2001 · 10.1126/science.291.5512.2429

Current projects

No projects listed.