Roy N. Alcalay

Research interests

Publications

• Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

  The Lancet Neurology · 2023 · 10.1016/s1474-4422(23)00109-6

• Incidence of Parkinson disease in North America

  npj Parkinson s Disease · 2022 · 10.1038/s41531-022-00410-y

• Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

  Science Advances · 2022 · 10.1126/sciadv.abm6393

• Urinary proteome profiling for stratifying patients with familial Parkinson’s disease

  EMBO Molecular Medicine · 2021 · 10.15252/emmm.202013257

• α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson’s disease from multiple system atrophy

  Acta Neuropathologica · 2021 · 10.1007/s00401-021-02324-0

• Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-26280-1

• Identification of Candidate Parkinson Disease Genes by Integrating Genome-Wide Association Study, Expression, and Epigenetic Data Sets

  JAMA Neurology · 2021 · https://doi.org/10.1001/jamaneurol.2020.5257

• Impact of the COVID ‐19 Pandemic on Parkinson's Disease and Movement Disorders

  Movement Disorders · 2020 · 10.1002/mds.28067

• Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

  The Lancet Neurology · 2019 · https://doi.org/10.1016/s1474-4422(19)30320-5

• Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia

  Brain · 2019 · 10.1093/brain/awz350

• GBA-Associated Parkinson’s Disease and Other Synucleinopathies

  Current Neurology and Neuroscience Reports · 2018 · 10.1007/s11910-018-0860-4

• Progression in the LRRK2-Associated Parkinson Disease Population

  JAMA Neurology · 2018 · 10.1001/jamaneurol.2017.4019

• Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non‐Ashkenazi Jewish ancestry

  Movement Disorders · 2017 · 10.1002/mds.27059

• T cells from patients with Parkinson’s disease recognize α-synuclein peptides

  Nature · 2017 · 10.1038/nature22815

• Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

  Movement Disorders · 2017 · 10.1002/mds.27193

• Arm swing as a potential new prodromal marker of Parkinson's disease

  Movement Disorders · 2016 · 10.1002/mds.26720

• Ser(P)‐1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

  Movement Disorders · 2016 · 10.1002/mds.26686

• Glucocerebrosidase activity in Parkinson’s disease with and without GBA mutations

  Brain · 2015 · 10.1093/brain/awv179

• Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

  Neurology · 2015 · 10.1212/wnl.0000000000001708

• Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

  Neurology · 2015 · 10.1212/wnl.0000000000001708

• Comparison of Parkinson Risk in Ashkenazi Jewish Patients With Gaucher Disease andGBAHeterozygotes

  JAMA Neurology · 2014 · 10.1001/jamaneurol.2014.313

• Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

  JAMA Neurology · 2014 · https://doi.org/10.1001/jamaneurol.2014.2704

• Use of Genetic Tests among Neurologists and Psychiatrists: Knowledge, Attitudes, Behaviors, and Needs for Training

  Journal of Genetic Counseling · 2013 · https://doi.org/10.1007/s10897-013-9624-0

• Cognitive performance of GBA mutation carriers with early-onset PD

  Neurology · 2012 · 10.1212/wnl.0b013e318253d54b

• The association between Mediterranean diet adherence and Parkinson's disease

  Movement Disorders · 2012 · 10.1002/mds.24918

• The neuropathology of genetic Parkinson's disease

  Movement Disorders · 2012 · 10.1002/mds.24962

Current projects

No projects listed.