Anthony H. Futerman

Research interests

Publications

• Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases

  Experimental & Molecular Medicine · 2019 · https://doi.org/10.1038/s12276-019-0340-1

• A Dynamic Interface between Vacuoles and Mitochondria in Yeast

  Developmental Cell · 2014 · https://doi.org/10.1016/j.devcel.2014.06.007

• CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

  Cell Metabolism · 2014 · 10.1016/j.cmet.2014.10.007

• CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

  Cell Metabolism · 2014 · 10.1016/j.cmet.2014.09.015

• Ceramide synthases as potential targets for therapeutic intervention in human diseases

  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2013 · 10.1016/j.bbalip.2013.08.019

• Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturation

  Biochimica et Biophysica Acta (BBA) - Biomembranes · 2011 · 10.1016/j.bbamem.2011.07.023

• Mammalian ceramide synthases

  IUBMB Life · 2010 · https://doi.org/10.1002/iub.319

• A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m109.077594

• A Critical Role for Ceramide Synthase 2 in Liver Homeostasis

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.m109.077610

• Common and Uncommon Pathogenic Cascades in Lysosomal Storage Diseases

  Journal of Biological Chemistry · 2010 · 10.1074/jbc.r110.134452

• Characterization of Ceramide Synthase 2

  Journal of Biological Chemistry · 2007 · https://doi.org/10.1074/jbc.m707386200

• The metabolism and function of sphingolipids and glycosphingolipids

  Cellular and Molecular Life Sciences · 2007 · 10.1007/s00018-007-7076-0

• Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system

  Plant Biotechnology Journal · 2007 · 10.1111/j.1467-7652.2007.00263.x

• When Do Lasses (Longevity Assurance Genes) Become CerS (Ceramide Synthases)?

  Journal of Biological Chemistry · 2006 · 10.1074/jbc.r600010200

• The ins and outs of sphingolipid synthesis

  Trends in Cell Biology · 2005 · 10.1016/j.tcb.2005.04.006

• Gaucher disease: pathological mechanisms and modern management

  British Journal of Haematology · 2005 · 10.1111/j.1365-2141.2004.05351.x

• The complex life of simple sphingolipids

  EMBO Reports · 2004 · https://doi.org/10.1038/sj.embor.7400208

• The cell biology of lysosomal storage disorders

  Nature Reviews Molecular Cell Biology · 2004 · https://doi.org/10.1038/nrm1423

• Two Mammalian Longevity Assurance Gene (LAG1) Family Members, trh1 and trh4, Regulate Dihydroceramide Synthesis Using Different Fatty Acyl-CoA Donors

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m307104200

• X‐ray structure of human acid‐β‐glucosidase, the defective enzyme in Gaucher disease

  EMBO Reports · 2003 · 10.1038/sj.embor.embor873

• Upstream of Growth and Differentiation Factor 1 (uog1), a Mammalian Homolog of the Yeast Longevity Assurance Gene 1 (LAG1), RegulatesN-Stearoyl-sphinganine (C18-(Dihydro)ceramide) Synthesis in a Fumonisin B1-independent Manner in Mammalian Cells

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m205211200

• The economics of neurite outgrowth — the addition of new membrane to growing axons

  Trends in Neurosciences · 1996 · 10.1016/s0166-2236(96)80025-7

• Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver

  Biochemical Journal · 1991 · 10.1042/bj2800295

• Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

  Journal of Biological Chemistry · 1990 · 10.1016/s0021-9258(19)38937-9

• Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins

  Trends in Biochemical Sciences · 1986 · 10.1016/0968-0004(86)90009-5

Current projects

No projects listed.