Marie Pancera

Research interests

Publications

• Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.06.001

• A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

  Immunity · 2020 · https://doi.org/10.1016/j.immuni.2020.08.014

• Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19231-9

• A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

  Nature Medicine · 2018 · https://doi.org/10.1038/nm.4512

• Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

  Cell Reports · 2017 · https://doi.org/10.1016/j.celrep.2017.04.013

• Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

  Science · 2016 · https://doi.org/10.1126/science.aae0474

• Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

  Nature Structural & Molecular Biology · 2016 · 10.1038/nsmb.3267

• Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.04.010

• Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.05.007

• Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

  Nature Structural & Molecular Biology · 2015 · https://doi.org/10.1038/nsmb.3051

• New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

  Journal of Virology · 2015 · https://doi.org/10.1128/jvi.01791-15

• Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

  Nature Structural & Molecular Biology · 2015 · https://doi.org/10.1038/nsmb.3144

• Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

  Nature · 2014 · https://doi.org/10.1038/nature13036

• Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

  Nature · 2014 · https://doi.org/10.1038/nature13601

• Structure and immune recognition of trimeric pre-fusion HIV-1 Env

  Nature · 2014 · https://doi.org/10.1038/nature13808

• Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.03.018

• Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

  Science · 2013 · https://doi.org/10.1126/science.1233989

• Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

  Immunity · 2013 · https://doi.org/10.1016/j.immuni.2012.11.011

• Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

  Nature Structural & Molecular Biology · 2013 · https://doi.org/10.1038/nsmb.2600

• Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

  Journal of Virology · 2011 · https://doi.org/10.1128/jvi.05045-11

• Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

  Nature · 2011 · https://doi.org/10.1038/nature10696

• Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

  Journal of Virology · 2010 · https://doi.org/10.1128/jvi.00966-10

• Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

  Molecular Cell · 2010 · https://doi.org/10.1016/j.molcel.2010.02.012

• Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

  Science · 2009 · https://doi.org/10.1126/science.1175868

• Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

  Proceedings of the National Academy of Sciences · 2009 · https://doi.org/10.1073/pnas.0911004107

• Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition

  Virology · 2003 · 10.1016/s0042-6822(03)00294-0

Current projects

No projects listed.