Li Hsu

Research interests

Publications

• Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations

  Nature Medicine · 2024 · 10.1038/s41591-024-02796-z

• Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

  Annals of Oncology · 2024 · 10.1016/j.annonc.2024.02.008

• Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

  BMC Medicine · 2020 · 10.1186/s12916-020-01855-9

• Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-14389-8

• Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

  Nature Communications · 2020 · 10.1038/s41467-020-17386-z

• Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

  The American Journal of Human Genetics · 2020 · https://doi.org/10.1016/j.ajhg.2020.07.006

• Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

  Gastroenterology · 2019 · 10.1053/j.gastro.2019.12.020

• Genetic Mechanisms of Immune Evasion in Colorectal Cancer

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-17-1327

• Strongly enhanced colorectal cancer risk stratification by combining family history and genetic risk score

  Clinical Epidemiology · 2018 · 10.2147/clep.s145636

• Update on the State of the Science for Analytical Methods for Gene-Environment Interactions

  American Journal of Epidemiology · 2017 · 10.1093/aje/kwx228

• Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data

  PLoS Genetics · 2016 · 10.1371/journal.pgen.1006493

• Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

  Gastroenterology · 2016 · 10.1053/j.gastro.2016.02.076

• Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

  Nature · 2015 · https://doi.org/10.1038/nature14878

• Association of Aspirin and NSAID Use With Risk of Colorectal Cancer According to Genetic Variants

  JAMA · 2015 · 10.1001/jama.2015.1815

• Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk

  Cancer Epidemiology Biomarkers & Prevention · 2015 · 10.1158/1055-9965.epi-14-1309

• Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

  Nature Communications · 2014 · 10.1038/ncomms5613

• Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits

  Nature Genetics · 2014 · 10.1038/ng.2962

• A Unified Mixed‐Effects Model for Rare‐Variant Association in Sequencing Studies

  Genetic Epidemiology · 2013 · 10.1002/gepi.21717

• Characterization of Gene–Environment Interactions for Colorectal Cancer Susceptibility Loci

  Cancer Research · 2012 · 10.1158/0008-5472.can-11-4067

• Meta-analysis of new genome-wide association studies of colorectal cancer risk

  Human Genetics · 2011 · 10.1007/s00439-011-1055-0

• Extreme variability among mammalian V1R gene families

  Genome Research · 2009 · 10.1101/gr.098913.109

• Prevalence and Predictors of BRCA1 and BRCA2 Mutations in a Population-Based Study of Breast Cancer in White and Black American Women Ages 35 to 64 Years

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-0503

• Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes

  Cancer Research · 2004 · 10.1158/0008-5472.can-04-1992

• Sequence Analysis Using Logic Regression

  Genetic Epidemiology · 2001 · 10.1002/gepi.2001.21.s1.s626

• HIV Quasispecies and Resampling

  Science · 1996 · 10.1126/science.273.5274.415

Current projects

No projects listed.