Mark Hatherill

Research interests

Publications

• Classification of early tuberculosis states to guide research for improved care and prevention: an international Delphi consensus exercise

  The Lancet Respiratory Medicine · 2024 · https://doi.org/10.1016/s2213-2600(24)00028-6

• RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

  Scientific Reports · 2020 · https://doi.org/10.1038/s41598-020-65043-8

• The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis

  The Lancet · 2020 · https://doi.org/10.1016/s0140-6736(20)30166-5

• Final Analysis of a Trial of M72/AS01 E Vaccine to Prevent Tuberculosis

  New England Journal of Medicine · 2019 · https://doi.org/10.1056/nejmoa1909953

• Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1714021

• Phase 2b Controlled Trial of M72/AS01 E Vaccine to Prevent Tuberculosis

  New England Journal of Medicine · 2018 · https://doi.org/10.1056/nejmoa1803484

• Four-Gene Pan-African Blood Signature Predicts Progression to Tuberculosis

  American Journal of Respiratory and Critical Care Medicine · 2018 · https://doi.org/10.1164/rccm.201711-2340oc

• Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease

  PLoS Pathogens · 2017 · 10.1371/journal.ppat.1006687

• Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

  Cell Host & Microbe · 2017 · 10.1016/j.chom.2017.05.012

• Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

  Cell Host & Microbe · 2017 · 10.1016/j.chom.2017.05.012

• A blood RNA signature for tuberculosis disease risk: a prospective cohort study

  The Lancet · 2016 · https://doi.org/10.1016/s0140-6736(15)01316-1

• T-cell activation is an immune correlate of risk in BCG vaccinated infants

  Nature Communications · 2016 · 10.1038/ncomms11290

• Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis

  European Respiratory Journal · 2016 · 10.1183/13993003.01012-2016

• Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis

  European Respiratory Journal · 2016 · 10.1183/13993003.01012-2016

• First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

  Vaccine · 2015 · 10.1016/j.vaccine.2015.06.051

• First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults

  Vaccine · 2015 · 10.1016/j.vaccine.2015.06.051

• High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmoa1314210

• Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial

  The Lancet · 2013 · https://doi.org/10.1016/s0140-6736(13)60177-4

• Evaluation of Tuberculosis Diagnostics in Children: 1. Proposed Clinical Case Definitions for Classification of Intrathoracic Tuberculosis Disease. Consensus From an Expert Panel

  The Journal of Infectious Diseases · 2012 · 10.1093/infdis/jis008

• The Utility of an Interferon Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection and Disease in Children

  The Pediatric Infectious Disease Journal · 2011 · 10.1097/inf.0b013e318214b915

• The Utility of an Interferon Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection and Disease in Children

  The Pediatric Infectious Disease Journal · 2011 · 10.1097/inf.0b013e318214b915

• The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

  American Journal of Respiratory and Critical Care Medicine · 2010 · 10.1164/rccm.200910-1484oc

• Specific T Cell Frequency and Cytokine Expression Profile Do Not Correlate with Protection against Tuberculosis after Bacillus Calmette-Guérin Vaccination of Newborns

  American Journal of Respiratory and Critical Care Medicine · 2010 · 10.1164/rccm.201003-0334oc

• The Novel Tuberculosis Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4+ and CD8+ T Cells in Adults

  American Journal of Respiratory and Critical Care Medicine · 2010 · 10.1164/rccm.200910-1484oc

• Modified vaccinia Ankara‐expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

  European Journal of Immunology · 2009 · 10.1002/eji.200939754

• Modified vaccinia Ankara‐expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4+ T cells

  European Journal of Immunology · 2009 · 10.1002/eji.200939754

• Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Healthy Adults in South Africa

  The Journal of Infectious Diseases · 2008 · 10.1086/590185

• Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Healthy Adults in South Africa

  The Journal of Infectious Diseases · 2008 · 10.1086/590185

• Procalcitonin and cytokine levels: Relationship to organ failure and mortality in pediatric septic shock

  Critical Care Medicine · 2000 · 10.1097/00003246-200007000-00068

• Procalcitonin and cytokine levels: Relationship to organ failure and mortality in pediatric septic shock

  Critical Care Medicine · 2000 · 10.1097/00003246-200007000-00068

• Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count

  Archives of Disease in Childhood · 1999 · 10.1136/adc.81.5.417

• Clinicians' abilities to estimate cardiac index in ventilated children and infants

  Archives of Disease in Childhood · 1997 · 10.1136/adc.77.6.516

• Clinicians' abilities to estimate cardiac index in ventilated children and infants

  Archives of Disease in Childhood · 1997 · 10.1136/adc.77.6.516

• Clinical validation of cardiac output measurements using femoral artery thermodilution with direct Fick in ventilated children and infants

  Intensive Care Medicine · 1997 · 10.1007/s001340050443

• Clinical validation of cardiac output measurements using femoral artery thermodilution with direct Fick in ventilated children and infants

  Intensive Care Medicine · 1997 · 10.1007/s001340050443

Current projects

No projects listed.