Jeroen R. Huyghe

Research interests

Publications

• Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

  Nature Genetics · 2022 · https://doi.org/10.1038/s41588-022-01222-9

• Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

  BMC Medicine · 2020 · https://doi.org/10.1186/s12916-020-01855-9

• Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

  The American Journal of Human Genetics · 2020 · https://doi.org/10.1016/j.ajhg.2020.07.006

• Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-14389-8

• Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.12.020

• Cumulative Burden of Colorectal Cancer–Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

  Gastroenterology · 2019 · https://doi.org/10.1053/j.gastro.2019.12.012

• Shared heritability and functional enrichment across six solid cancers

  Nature Communications · 2019 · https://doi.org/10.1038/s41467-018-08054-4

• Discovery of common and rare genetic risk variants for colorectal cancer

  Nature Genetics · 2018 · https://doi.org/10.1038/s41588-018-0286-6

• Genetic Mechanisms of Immune Evasion in Colorectal Cancer

  Cancer Discovery · 2018 · https://doi.org/10.1158/2159-8290.cd-17-1327

• Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

  Gastroenterology · 2018 · https://doi.org/10.1053/j.gastro.2018.02.021

• Novel Common Genetic Susceptibility Loci for Colorectal Cancer

  JNCI Journal of the National Cancer Institute · 2018 · https://doi.org/10.1093/jnci/djy099

• The genetic regulatory signature of type 2 diabetes in human skeletal muscle

  Nature Communications · 2016 · 10.1038/ncomms11764

• Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3654

• Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia

  The American Journal of Human Genetics · 2016 · https://doi.org/10.1016/j.ajhg.2016.05.028

• The genetic architecture of type 2 diabetes

  Nature · 2016 · https://doi.org/10.1038/nature18642

• Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1410428111

• Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2507

• Occupational Noise, Smoking, and a High Body Mass Index are Risk Factors for Age-related Hearing Impairment and Moderate Alcohol Consumption is Protective: A European Population-based Multicenter Study

  Journal of the Association for Research in Otolaryngology · 2008 · https://doi.org/10.1007/s10162-008-0123-1

• GRM7 variants confer susceptibility to age-related hearing impairment

  Human Molecular Genetics · 2008 · https://doi.org/10.1093/hmg/ddn402

• The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment

  Human Molecular Genetics · 2007 · 10.1093/hmg/ddm292

Current projects

No projects listed.