Christine Skerka

Research interests

Publications

• ApoE attenuates unresolvable inflammation by complex formation with activated C1q

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-018-0336-8

• Atypical aHUS: State of the art

  Molecular Immunology · 2015 · https://doi.org/10.1016/j.molimm.2015.03.246

• Complement factor H related proteins (CFHRs)

  Molecular Immunology · 2013 · https://doi.org/10.1016/j.molimm.2013.06.001

• Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

  Nature · 2011 · https://doi.org/10.1038/nature10449

• An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

  Human Molecular Genetics · 2010 · https://doi.org/10.1093/hmg/ddq399

• Complement regulators and inhibitory proteins

  Nature reviews. Immunology · 2009 · https://doi.org/10.1038/nri2620

• The yeast Candida albicans evades human complement attack by secretion of aspartic proteases

  Molecular Immunology · 2009 · https://doi.org/10.1016/j.molimm.2009.08.019

• Factor H–related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

  Blood · 2009 · https://doi.org/10.1182/blood-2009-02-205641

• Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

  PLoS Genetics · 2007 · https://doi.org/10.1371/journal.pgen.0030041

• Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency

  Blood · 2007 · https://doi.org/10.1182/blood-2007-09-109876

• Anti–factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome

  Blood · 2007 · https://doi.org/10.1182/blood-2007-02-071472

• Defective complement control of Factor H (Y402H) and FHL-1 in age-related macular degeneration

  Molecular Immunology · 2007 · https://doi.org/10.1016/j.molimm.2007.02.012

• Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

  Kidney International · 2006 · https://doi.org/10.1038/sj.ki.5000269

• Complement and diseases: Defective alternative pathway control results in kidney and eye diseases

  Molecular Immunology · 2005 · https://doi.org/10.1016/j.molimm.2005.06.015

• Complement Resistance of Borrelia burgdorferi Correlates with the Expression of BbCRASP-1, a Novel Linear Plasmid-encoded Surface Protein That Interacts with Human Factor H and FHL-1 and Is Unrelated to Erp Proteins

  Journal of Biological Chemistry · 2004 · https://doi.org/10.1074/jbc.m308343200

• Factor H family proteins: on complement, microbes and human diseases

  Biochemical Society Transactions · 2002 · https://doi.org/10.1042/bst0300971

• Immune evasion ofBorrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and Factor H

  European Journal of Immunology · 2001 · https://doi.org/10.1002/1521-4141(200106)31:6<1674::aid-immu1674>3.0.co;2-2

• The Molecular Basis of Familial Hemolytic Uremic Syndrome

  Journal of the American Society of Nephrology · 2001 · https://doi.org/10.1681/asn.v122297

• Further Characterization of Complement Regulator-Acquiring Surface Proteins ofBorrelia burgdorferi

  Infection and Immunity · 2001 · https://doi.org/10.1128/iai.69.12.7800-7809.2001

• Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1

  The Journal of Immunology · 1995 · https://doi.org/10.4049/jimmunol.155.12.5663

Current projects

No projects listed.