Alfredo Martı́nez

Research interests

Publications

• Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

  Journal of Clinical Investigation · 2019 · 10.1172/jci123825

• Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

  Oncogene · 2011 · 10.1038/onc.2011.335

• Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

  Cancer Research · 2011 · 10.1158/0008-5472.can-10-1733

• The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers

  Journal of Clinical Investigation · 2008 · 10.1172/jci30024

• Tumor-Derived Interleukin-8 Stimulates Osteolysis Independent of the Receptor Activator of Nuclear Factor-κB Ligand Pathway

  Cancer Research · 2005 · 10.1158/0008-5472.can-05-2630

• The role of free radicals in cerebral hypoxia and ischemia

  Free Radical Biology and Medicine · 2005 · 10.1016/j.freeradbiomed.2005.02.010

• A Role for the RASSF1A Tumor Suppressor in the Regulation of Tubulin Polymerization and Genomic Stability

  Cancer Research · 2004 · 10.1158/0008-5472.can-04-0339

• Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator

  Biochemical Journal · 2004 · 10.1042/bj20040920

• Expression of Complement Factor H by Lung Cancer Cells

  Cancer Research · 2004 · 10.1158/0008-5472.can-03-2328

• Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets

  Diabetologia · 2004 · 10.1007/s00125-004-1618-x

• Adrenomedullin and cancer

  Regulatory Peptides · 2003 · 10.1016/s0167-0115(03)00037-5

• Cell and molecular biology of the multifunctional peptide, adrenomedullin

  International review of cytology · 2002 · 10.1016/s0074-7696(02)21010-4

• Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m204733200

• Five‐lipoxygenase inhibitors can mediate apoptosis in human breast cancer cell lines through complex eicosanoid interactions

  The FASEB Journal · 2001 · 10.1096/fj.00-0866fje

• Complement Factor H Is a Serum-binding Protein for Adrenomedullin, and the Resulting Complex Modulates the Bioactivities of Both Partners

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m007822200

• Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis

  Molecular Endocrinology · 2000 · https://doi.org/10.1210/mend.14.6.0473

• Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors.

  PubMed · 1999

• Expression of Adrenomedullin and Its Receptor during Embryogenesis Suggests Autocrine or Paracrine Modes of Action

  Endocrinology · 1997 · 10.1210/endo.138.1.4881

• Adrenomedullin Expression in Human Tumor Cell Lines ITS POTENTIAL ROLE AS AN AUTOCRINE GROWTH FACTOR

  Journal of Biological Chemistry · 1996 · https://doi.org/10.1074/jbc.271.38.23345

• Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling.

  Journal of Clinical Investigation · 1996 · https://doi.org/10.1172/jci118480

• Regulation of insulin secretion and blood glucose metabolism by adrenomedullin.

  Endocrinology · 1996 · 10.1210/endo.137.6.8641217

• Expression of adrenomedullin in normal human lung and in pulmonary tumors

  Endocrinology · 1995 · 10.1210/en.136.9.4099

• Expression of adrenomedullin in normal human lung and in pulmonary tumors.

  Endocrinology · 1995 · 10.1210/endo.136.9.7649118

• Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies

  American Journal of Physiology-Cell Physiology · 1993 · 10.1152/ajpcell.1993.265.5.c1379

• Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

  Development · 1993 · https://doi.org/10.1242/dev.118.4.1031

Current projects

No projects listed.