Nelson Dusetti

Research interests

Publications

• Activation of lysosomal iron triggers ferroptosis in cancer

  Nature · 2025 · 10.1038/s41586-025-08974-4

• Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer

  Nature Communications · 2022 · 10.1038/s41467-022-29659-w

• Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer

  Exploration · 2021 · 10.1002/exp.20210003

• Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype

  The FASEB Journal · 2020 · 10.1096/fj.202000363rr

• Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

  Cell Reports Medicine · 2020 · 10.1016/j.xcrm.2020.100143

• Prognostic significance of circulating PD-1, PD-L1, pan-BTN3As, BTN3A1 and BTLA in patients with pancreatic adenocarcinoma

  OncoImmunology · 2019 · 10.1080/2162402x.2018.1561120

• Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

  Nature Communications · 2019 · 10.1038/s41467-019-11812-7

• Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

  Cancer Cell · 2019 · 10.1016/j.ccell.2019.03.002

• Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-04383-6

• Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas

  Gastroenterology · 2017 · 10.1053/j.gastro.2017.11.009

• Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

  Cell Reports · 2017 · 10.1016/j.celrep.2017.11.003

• GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

  Gut · 2016 · https://doi.org/10.1136/gutjnl-2015-311256

• Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness

  Journal of Clinical Investigation · 2016 · 10.1172/jci87734

• Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling

  Cell Death and Disease · 2015 · 10.1038/cddis.2014.557

• Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1219555110

• TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

  Cell Death and Differentiation · 2012 · 10.1038/cdd.2012.30

• Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1

  Cancer Research · 2008 · 10.1158/0008-5472.can-08-0769

• Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

  Cancer Research · 2008 · 10.1158/0008-5472.can-08-2320

• Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

  Proceedings of the National Academy of Sciences · 2007 · https://doi.org/10.1073/pnas.0703942104

• TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

  Oncogene · 2005 · 10.1038/sj.onc.1208951

• TP53INP1s and Homeodomain-interacting Protein Kinase-2 (HIPK2) Are Partners in Regulating p53 Activity

  Journal of Biological Chemistry · 2003 · 10.1074/jbc.m301979200

• Tumor necrosis factor α triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation

  Gastroenterology · 2000 · 10.1053/gast.2000.16491

• The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis

  Gastroenterology · 1998 · 10.1016/s0016-5085(98)70595-5

• Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis

  International Journal of Cancer · 1997 · 10.1002/(sici)1097-0215(19970220)74:1<35::aid-ijc7>3.0.co;2-1

• Pancreatitis-associated Protein I (PAP I), an Acute Phase Protein Induced by Cytokines

  Journal of Biological Chemistry · 1995 · 10.1074/jbc.270.38.22417

Current projects

No projects listed.