Henry van den Bedem

Research interests

Publications

• AI is a viable alternative to high throughput screening: a 318-target study

  Scientific Reports · 2024 · 10.1038/s41598-024-54655-z

• Ligand binding remodels protein side-chain conformational heterogeneity

  eLife · 2022 · 10.7554/elife.74114

• qFit 3: Protein and ligand multiconformer modeling for X‐ray crystallographic and single‐particle cryo‐EM density maps

  Protein Science · 2020 · 10.1002/pro.4001

• Mix-and-inject XFEL crystallography reveals gated conformational dynamics during enzyme catalysis

  Proceedings of the National Academy of Sciences · 2019 · 10.1073/pnas.1901864116

• Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

  eLife · 2015 · 10.7554/elife.07574

• Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit

  PLoS Computational Biology · 2015 · 10.1371/journal.pcbi.1004507

• Integrative, dynamic structural biology at atomic resolution—it's about time

  Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3324

• Crystal Cryocooling Distorts Conformational Heterogeneity in a Model Michaelis Complex of DHFR

  Structure · 2014 · 10.1016/j.str.2014.04.016

• Integrated description of protein dynamics from room-temperature X-ray crystallography and NMR

  Proceedings of the National Academy of Sciences · 2014 · 10.1073/pnas.1323440111

• Automated identification of functional dynamic contact networks from X-ray crystallography

  Nature Methods · 2013 · 10.1038/nmeth.2592

• Accessing protein conformational ensembles using room-temperature X-ray crystallography

  Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1111325108

• Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers

  Acta Crystallographica Section D Biological Crystallography · 2009 · 10.1107/s0907444909030613

• New paradigm for macromolecular crystallography experiments at SSRL: automated crystal screening and remote data collection

  Acta Crystallographica Section D Biological Crystallography · 2008 · 10.1107/s0907444908030564

• Crystal structures of two novel dye‐decolorizing peroxidases reveal a β‐barrel fold with a conserved heme‐binding motif

  Proteins Structure Function and Bioinformatics · 2007 · 10.1002/prot.21550

• Automated diffraction image analysis and spot searching for high-throughput crystal screening

  Journal of Applied Crystallography · 2006 · 10.1107/s0021889805040677

Current projects

No projects listed.